Category: dhxqlckq

Flying Lotus Drops Seven New Tracks Including ‘Twin Peaks’ Theme Remix And Collaborations With Thundercat

first_imgAs a culmination of the four releases from yesterday, Flying Lotus released another track with the title, “You’re Dead! THUNDERDETH LOTUS – North Star3.” The song features all of the guest artists featured yesterday—Miguel Atwood-Fergueson, Thundercat and Brendon Small—and is a brooding and cascading song. You can take a listen below, and keep your eyes peeled for new work from Flying Lotus on the way! The release of “Twin Peaks” seemingly kicked off a flood of new songs from Flying Lotus, as it was shortly followed by “Night Grows Pale.” This second track revolves around a sample of Freddie Mercury’s vocals from Queen’s “White Queen (As It Began)” off of Queen II. The ethereal and dreamy track can be heard below.Yesterday, FlyLo dropped four new songs. First, he released a new track called “Crowned” from his animated rapper alter-ego Captain Murphy, a character created for his 2012 mixtape Duality. He also released two different versions of his theme for the film LoveTrue, which is now available on Netflix—both versions feature Miguel Atwood-Fergueson. Finally, the producer released a heavy-metal collaboration with Thundercat and Brendon Small from Dethklok. You can listen to these newest songs below. The experimental Los Angeles-based producer Flying Lotus has certainly been on a music kick, dropping seven new tracks over the past three days, marking his first releases to his Soundcloud in over a year since March of 2016. Over the past few months, the Brainfeeder founder has been focusing on film—in January, he made his directorial debut with the horror film, Kuso. While FlyLo collaborated with Thundercat on Drunk, Flying Lotus hasn’t released an album since 2014 with the release of You’re Dead!, so perhaps these new batches of songs are hinting at new music in the works.Thundercat Releases New Album “Drunk” Featuring Flying Lotus, Kendrick Lamar, & MoreThe first track was a remix of the Twin Peaks theme, the 90’s cult classic by David Lynch which will see its comeback on Showtime later in the week. The  remix had been debuted live at Upstream Music Fest in Seattle over the weekend, though FlyLo released the studio version a few days later via Soundcloud, which you can hear below.last_img read more

How a child made scientists think of cytokines as knobs instead of switches

first_imgAn unusual case of a rare anemia is opening scientists up to a new way of thinking about how to adapt and employ cytokines, messenger molecules of the blood and immune system, as tools for treatment — tools that are more analog than digital — and to illustrate the promise of precision medicine.Cytokines are workhorses of a vast messaging network used by the blood and immune systems. These proteins influence all manner of activity in these systems, from inflammation to resolution, cell production to cell death.Conventional wisdom has held that cytokines are “digital,” in that they either bind to a cellular receptor — triggering a cascade of signals within the cell — or they don’t. If a mutation prevents perfect binding, no cascade. There is no middle ground.But maybe there is. A rare case of a rare disease has led an international research team headed by Broad Institute of Harvard and MIT associate member Vijay Sankaran of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, postdoctoral fellow Ah Ram Kim, and Yale University’s Daryl Klein to propose an “analog” view of cytokine function. It may be, as they show in Cell, that cytokine mutations that affect not whether a protein and receptor interact, but the quality of that interaction, can tune a cell’s biochemical response, triggering some signals and not others.This insight could give researchers an opening to develop cytokine-based therapeutics tailored to elicit particular activities — potentially a boon for people suffering forms of cancer, kidney disease, blood disorders, and more.The story of how the team came to this understanding begins with a child.An unusual caseA few years ago, Sankaran’s colleagues at Dana-Farber/Boston Children’s (where he is a pediatric hematologist/oncologist) cared for a young boy diagnosed with Diamond-Blackfan anemia (DBA), a rare blood disorder in which the bone marrow cannot produce red blood cells (RBCs). Transfusions kept the disorder more or less at bay, but when the boy was 6, his family and physicians agreed it was time for a bone marrow transplant.“A transplant cures most cases of DBA,” said Sankaran. “But the child still required transfusions [after the procedure], which is very unusual for this disorder.” (Ultimately, the child passed away from a transplant-related complication.)Also unusual was the fact that neither of the boy’s parents, who are first cousins, showed signs of the disorder.“Most of the mutations that cause DBA are transmitted from parent to child in a dominant fashion,” said Sankaran. “But because neither parent was affected, we wondered whether in this case there might be another, recessive cause.”Whole exome sequencing of the boy’s DNA did not uncover any of the known DBA-related gene mutations. It did, however, reveal a mutation in the gene for erythropoietin (EPO), a cytokine that controls RBC production.When messages failAs Sankaran and his collaborators probed more deeply into the boy’s case, a picture of a devastating cellular miscommunication began to emerge.First, the boy’s medical records revealed that his blood EPO levels — monitored during his transfusion treatments — were consistently 100 times higher than normal.Second, the mutation itself (a change in a single base pair) is not recorded in the Exome Aggregation Consortium (ExAC) database, suggesting it is exceedingly rare.Third, when the team studied the mutated gene’s altered protein product, they found the mutation did not change whether the protein could bind to its receptor, EPOR, on blood precursor cells. Rather, it changed the cytokine’s binding kinetics — the rates at which EPO and EPOR bound (associated) and unbound (dissociated). The mutant protein’s association rate was 12 times higher than a normal EPO’s; its dissociation rate, 233 times higher.Normally, when tripped by EPO, EPOR alerts three transcription factors — STAT1, STAT3, and STAT5 — to kick-start the gene program for RBC production. However, Sankaran and Klein’s team found, the mutant EPO’s quick hit did not provide EPOR a strong enough nudge to alert STAT1 and 3. Without them, the blood precursors could not start making RBCs.So the boy’s body, sensing the lack of RBCs, kept churning out EPO, pleading with the bone marrow to make the cells it needed. But because of the mutation, EPOR could not hear the message well enough to do its job.Tuning in to a new ideaIn addition to explaining the child’s grave disease, the findings suggest something new: a different way to think about adapting cytokines therapeutically.“In hematology and immunology, people tend to think about cytokines as working like on and off switches,” Sankaran said. Doctors commonly use or manipulate EPO and other cytokines to treat cancer, autoimmunity, immunodeficiencies, and other conditions, he said. “But what we’re learning is that maybe they can be tuned.”Sankaran points to G protein-coupled receptors (GPCRs) — a family of multifunctional receptors and popular drug development targets — as a framework for thinking about the tunable cytokine activity he and his teammates propose. By modifying a cytokine and altering how it interacts with its receptor, it may be possible to nudge that receptor toward a therapeutic response and away from a deleterious one.“Maybe we could do better and design agents that act to stimulate some cell types or signaling pathways better than others,” Sankaran mused. “There are other cytokines that we know can stimulate blood production, but that we haven’t used because they have a lot of side effects. Those are the kinds of problems that we’d like to tackle now that we have this knowledge.”Putting precision pediatrics into practiceAs this story started with a child, so too does it end with one.As Sankaran and Klein were revising their work for publication, the boy’s parents had another baby, a little girl. She too was profoundly anemic, had sky-high blood levels of EPO, and had the same EPO mutation.Leveraging what they learned from her brother’s case, Sankaran asked his clinical partners to start treating the infant with recombinant EPO. So far, it seems to be turning the tide.“We always say as geneticists that our goal is to be able to understand a mutation, translate that, and develop a therapy,” Sankaran said. “So we were really frustrated when we finally understood her older brother’s diagnosis because we have recombinant EPO and use it regularly. We could have saved his life, but just didn’t have that opportunity.“Here we had a chance to take a precision medicine approach, and it’s working remarkably well,” he continued. “It’s incredibly satisfying to be able to take what we’ve learned, put it into practice, and help a child and family.”last_img read more

See You at SAPPHIRE NOW 2017

first_imgJust as Dell EMC World wraps, we’re gearing up for another big event – SAPPHIRE NOW, SAP’s largest global business technology event, in Orlando (FL), May 16-18, 2017.Dell EMC and SAP have built a strong relationship over nearly two decades, covering system design and delivery, and extensive services expertise at every level. With a focus on the future, Dell EMC has expanded its investment in the advanced analytics space, including building a Global SAP Center of Excellence to foster a tighter partnership and greater co-innovation with SAP. This heightened level of collaboration has led to great industry benchmarks and exceptional customer results.At SAPPHIRE NOW, we’ll be sharing more about how that collaboration enables us to help customers realize digital transformation. If you are attending, come to booth #758 to meet the Dell EMC family.. We are looking forward to discussing with you how to transform IT to run SAP® in the digital business – from the edge to the core, and how to innovate your IT with leading infrastructure solutions to take the best advantage of the in-memory speed of SAP HANA®.Don’t miss out on these Dell EMC highlights during these three days of networking!Dell Technologies CEO Michael Dell will be present at the showLearn about Dell EMC portfolio for SAP including the full continuum of solutions:from build (ready nodes, bundles, and systems) to buy (converged and hyper-converged systems, hybrid cloud platforms)Dell EMC booth theatre with short and crisp business and technology focused sessions from the Dell EMC family and friendsSAP theatre session with Dell EMC on “SAP HANA Innovation and Optimization Using SAP IoT Foundation on Dell Gateways”Daily sweepstake in our booth #758The combination of Dell and EMC brings together two industry-leading companies with strong reputation for value and innovation. Dell EMC holds leadership positions in some of the biggest and largest growth categories in the IT infrastructure business, and that means customers can confidently source all their IT needs from one provider — Dell EMC.Stay tuned for more information – and see you on site in Orlando! Schedule a personal meeting with our experts!last_img read more

Watch the Entire Miss Saigon 25th Anniversary Gala Finale, With Lea Salonga & More

first_imgWe previously brought you a teaser trailer, now watch the entire Miss Saigon 25th gala finale. The celebration took place following a special performance of the West End revival on September 22 and it does not disappoint (of course it doesn’t). Following the show, original members of the Boublil and Schönberg musical took to the stage and joined the current cast. Lea Salonga and Rachelle Ann Go’s rendition of “The Movie in My Mind” will make your jaws drop, there’s a slight kerfuffle thanks to original Chris, Simon Bowman, and Jonathan Pryce’s ad-libs during “The American Dream” are priceless. Now all we need to know is: when is the show returning to Broadway? View Commentslast_img read more

Solar Power

first_imgUsing the sun as a power source isn’t a new concept. But for some Georgia farmers, implementing solar power to deliver water to remote locations is making a huge difference.With the help of funding from the USDA Natural Resources Conservation Service, University of Georgia Extension water resource specialist Gary Hawkins is studying the use of solar power for livestock watering and small irrigation systems.Solar power captured by panels runs pumps used to deliver water to cattle in remote areas of fields. Hawkins is using the system for livestock watering, but it can also be used effectively for small-scale irrigation, particularly for vegetable or fruit plots where power isn’t an option. Hawkins, who’s based on the UGA campus in Tifton, believes systems are “very economical for small-scale pumping” if they are located a distance from a power source — at least a quarter of a mile.“Typically, the system works very well in remote locations, especially economically,” Hawkins said. “The sun is collected by the solar panel which excites the silicon atoms and releases electrons. Those electrons are then transferred through whatever load you have. In the case of water pumping it is the pump. The panel works like a battery as long as the sun is shining, even a little. These pumps are DC pumps.” Pumping flow rates are related to depth of ground water. There are no direct solar pumps (DC power) to pump large volumes, but if the requirement is large volumes of water, then the DC power from solar panels can be converted to AC power and operate any size pump.As with most systems, solar power has advantages and disadvantages. The resource is free, can be used in remote locations and has the ability to pump a lot of water quickly. A small cattle watering system — for about 75 head of cattle — cost between $6,000 and $9,000, including installation.The solar panels have a 25-year warranty and general maintenance includes keeping the panels clean. If it doesn’t rain periodically, the panels could get covered with dust or pollen, which will interfere with the collection of sunlight. Cleaning the panels simply involves sweeping the dust or pollen off or just pouring on water to wash it away.During 2013 field days and workshops, Hawkins presented the solar power option to farmers and had more than 500 potential suitors. He and UGA County Extension agents received numerous phone calls about solar use, and more than 50 farmers expressed interest in pursuing contracts for solar power installation.“I wouldn’t say it’s the way of the future even though it has been getting a lot of attention lately. I would say it’s another option for farmers who have livestock or small irrigation needs outside or in remote locations,” Hawkins said. “I think it’s just another option we have for transferring water.”For more information about Hawkins’ research at UGA, see read more

The banking aisle – What CUs can learn from almond milk

first_imgby: Bradley BlueCredit union marketers – some food for thought:Almond milk is healthier than cow’s milk in many ways. It has more vitamins than regular milk, fewer calories, less fat, no sugar, no cholesterol, and takes significantly longer to expire. The product is popular with animal rights and environmental groups alike, and is widely promoted as an ethical alternative in these circles. Despite many competitive advantages, and despite not needing refrigeration, it sold only to a niche market until they put it in the refrigerated section next to the milk. (See article.) The mere fact that the two products were presented next to one another reduced consumer confusion about the product and increased the likelihood of purchase.While moving to the dairy aisle kept almond milk from being “out of sight, out of mind,” the biggest win for Almond Milk was that they were able to maintain a distinction from milk while still being presented in the same environment. Had they decided to market as milk, they would have been intentionally hiding their best attributes to fit in with a lesser competitor. It is also worth considering that dairy could not have matched such a move by putting its product in the baking aisle. While almond milk is able to compete on two aisles, milk must be refrigerated.Similarly, credit unions compete favorably with banks in many ways. They have better rates, fewer fees, better service, etc, and are widely advocated by consumer rights groups, but few recognize them as an alternative to banks or consider them when making a purchasing decision. Instead, we remain the curiously named, mysterious little box in the baking aisle. You know, the one your new-agey activist friend is always telling you to try. continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

The “first date” with your member—will you get a second?

first_img 2SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr When a brand new member takes the time (and it’s usually on their lunch hour) to walk into your branch to “move” their checking account – there is no bigger moment than that. Think about it. How did they choose you out of all the options available today? Something worked. Marketing, positive word-of-mouth, location, social media, community involvement, reputation. Here they are standing in your lobby. What happens next? Do you make them “sign in” and have a seat in a sad waiting room with old magazines, waiting for their name to be called (similar to a doctor or dentist appointment). This is called the “moment of truth.” Our product is service, and it’s manufactured with the member present. You will never ever get a second chance at this first impression. And yet, in most credit unions that survey members using Net Promoter Score, this “transaction” is consistently rated the lowest. And why is that? I think we are “shackled” with the “have tos”:We have to qualify them for membership We have to make sure they are not a terroristWe have to make sure they aren’t a horrible risk, and often put unreasonable holds on their initial deposit, or worse yet, consider them on “probation” for the first few monthsWe have to figure out which of our five checking account options is best for themThen we have to deal with our clunky core system and finally We have to tell them this pain has just begun…there is no bigger chore than moving all the things tied to your checking account. And if you hand them a “switch kit” you’ve just put the pain in a pamphletIt’s a wonder we ever get a second date. If you think this might be happening in your lobby, attend the CloudCherry webinar on July 30th where I will show you how to re-engineer your process using member journey mapping and improve the initial experience so you’re sure to have a long lasting member relationship that results in creating a profitable promoter. Click here to register. I can’t wait to see you there!last_img read more

Pula one step closer to the construction of a cruise terminal

first_imgPula is a big step closer to the construction of a cruise terminal in the port, which in the future can bring over 200 cruise arrivals and more than half a million passengers. For comparison, in recent years there have been about 60 cruise ship arrivals with less than 10.000 passengers, writes Voice of Istria. The ship’s passenger terminal in the port of Pula would be built north of the waterfront, on the stretch of Cape Guc. The construction of the terminal would ensure the possibility of mooring as many as three ships, and an additional advantage is that ships can enter and leave the terminal much easier because the depth of the sea there is 12 meters. The plan is to build three terminals, a pier and other ancillary facilities for ships. In the first phase, the construction of a terminal, a 400-meter-long pier, which would be connected to the mainland, is planned.”Just last week, we received a statement from the Ministry of Finance on the project of building a maritime passenger terminal in the port of Pula on Cape Guc. After we reported this project to the Ministry of Economy on the list of projects of strategic importance for the Republic of Croatia, the ministry asked all other ministries to comment on the project, which we worked on in cooperation with the Ministry of the Sea, Transport and Infrastructure. The obtained statement of the Ministry of Finance is without objections, especially since we have already prepared a Feasibility Study and Cost Analysis. Now we have to make an investment plan for a five-year period. In addition, we received 65.000 euros to conduct seabed testing, ie to conduct geomechanical research. Everything to see how the project would develop and how the construction would be done ”, he told Glas Istre Director of the Port of Pula Donald de Gravisi on the terminal project in the Port of Pula, due to which the then State Office for State Property Management (DUUDI) allocated for permanent use to the Port of Pula 14 hectares of state land in Vellelung.The entire project, from the construction of the coast and all facilities, ie complete infrastructure, would cost from 120 to 150 million euros. By the way, last year the number of trips of foreign ships for cruises decreased by 16,2%, and the number of passengers on these ships decreased by 13,3% compared to the same period in 2016. The total number of days of ships in the same period decreased by 16,9%Attachment: Feasibility study / cost-benefit analysis of the construction of a passenger terminal in PulaRELATED NEWS: LESS AND LESS CRUISES ON THE ADRIATIClast_img read more

Russian pension funds set for more secure future

first_imgThe Russian press additionally reported that there would be no further moratoriums on pension contributions in 2016.Medvedev explained that he based his decision on expert advice and public opinion.In a recent poll conducted by Public Opinion Foundation, 62% of those surveyed opposed the abolition of a funded pension system.The main reasons for their view were poorer retirement prospects and losing the opportunity to save for their retirement.Medvedev’s announcement is a victory for the finance and economy ministries and Bank of Russia over the government’s “social” bloc, spearheaded by Olga Golodets, deputy prime minister for social affairs, and Maxim Topilin, minister of labour and social protection.The social bloc’s arguments for either making the second-pillar voluntary or even abolishing it included what they considered to be poor returns generated by the scheme.In 2014, according to Bank of Russia, NSPF nominal returns averaged 4.9% compared with an inflation rate of 11.4%, although individual fund returns ranged between 0.2% and 52%.However, the fund run by the state-owned Vnesheconombank (VEB) for those citizens who did not choose a private NSPF returned only 2.68%.Last year proved disastrous for conservatively orientated funds investing in government securities, notably VEB, as sharp interest rate hikes by the central bank pushed up bond yields.Meanwhile, the 24 NSPFs that had, as of 1 March, converted from non-profit to joint-stock company status, gained central bank accreditation and signed up to the guarantee scheme administered by Deposit Insurance Agency (DIA) will receive the contributions frozen in the second half of 2013 and held at VEB by the end this May.Funds that register later will get their contributions from the third quarter of this year.In April, the central bank approved two more funds to join the DIA.The collective RUB947bn (€17bn) in pension savings accounts for some 85% of the total.Mandatory second-pillar funds that fail to complete this process by the start of 2016 will be liquidated. Russia’s non-state pension fund (NSPF) system appears more secure after the government ended months of speculation over its fate.Today, Russian prime minister Dmitry Medvedev announced at a government meeting that the country would continue with the accumulative mandatory second pillar.Medvedev has instructed Igor Shuvalov, first deputy prime minister, to produce proposals to balance the budget and produce more effective measure for the long-term use of pension fund assets.The decision follows on from yesterday’s announcement by the Kremlin’s press service that, following a meeting with government members at the start of the month, president Vladimir Putin instructed the government and Bank of Russia, the central bank and pensions regulator, to devise mechanisms for channelling NSPF assets into long-term investment projects, and to assess financing volumes.last_img read more

Bernardino confirmed for further five-year term at EIOPA

first_img“We will proceed with building a modern, dynamic and credible supervisory authority, working for the public good with a truly European spirit,” he said.Bernardino began his European career at CEIOPS, being elected its chairman in 2009.Prior to taking on the role of chairman at CEIOPS, and later being named as EIOPA’s inaugural chairman, he was director general for development and institutional relations at the Instituto de Seguros de Portugal (ISP), which he joined in 1989.He has already offered a glimpse of his second term’s focus, proposing the development of a framework for cross-border occupational defined contribution.The chairman has also repeatedly called for an overhaul of EIOPA’s funding model and, according to officials at the European Commission, is likely to reveal details of a new funding model early next year. The European Parliament has endorsed Gabriel Bernardino for a second term as chairman of the European Insurance and Occupational Pensions Authority (EIOPA).In a statement released following a vote by the parliament’s economic and monetary affairs committee (ECON), Bernardino said he was thankful for the trust of both the parliamentarians and EIOPA’s board of supervisors, which in October extended his term until 2021.“In the past five years,” Bernardino added, “EIOPA has grown into an entity with a strong voice and has been a driving force in regulatory convergence.”He said EIOPA’s next journey would be to deliver a “strategic shift from regulation to supervision” and to focus on consumer protection and the financial stability of the EU.last_img read more